Bopindolol
Names
[ CAS No. ]:
62658-63-3
[ Name ]:
Bopindolol
[Synonym ]:
[1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl] benzoate
Biological Activity
[Description]:
[Related Catalog]:
[Target]
β2 adrenoceptor
Beta-1 adrenergic receptor
Beta-3 adrenergic receptor
[In Vivo]
[References]
Chemical & Physical Properties
[ Density]:
1.143 g/cm3
[ Boiling Point ]:
557ºC at 760 mmHg
[ Molecular Formula ]:
C23H28N2O3
[ Molecular Weight ]:
380.48000
[ Flash Point ]:
290.7ºC
[ Exact Mass ]:
380.21000
[ PSA ]:
63.35000
[ LogP ]:
4.85970
[ Index of Refraction ]:
1.592
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UB3773750
- CHEMICAL NAME :
- 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((2-methyl-1H-indol-4- yl)oxy)-, benzoate (ester), (+-)-
- CAS REGISTRY NUMBER :
- 62658-63-3
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C23-H28-N2-O3
- MOLECULAR WEIGHT :
- 380.53
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 17 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2635209 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3 gm/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - other effects to embryo
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 26,115,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1188 mg/kg
- SEX/DURATION :
- female 7-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,4373,1989
Safety Information
[ HS Code ]:
2933990090
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%