Ethylthiourea
Names
[ CAS No. ]:
625-53-6
[ Name ]:
Ethylthiourea
[Synonym ]:
Urea,1-ethyl-2-thio
Ethylthiourea
MFCD00004939
methanethiol, 1-(ethylamino)-1-imino-
N-Ethylcarbamimidothioic acid
Thiourea,ethyl
N-Ethylthiocarbamide
N-ETHYLTHIOUREA
Thiourea,N-ethyl
Ethyl-2-thiourea
1-ethyl-2-thiourea
EINECS 210-899-3
1-Ethylthiourea
ethyl thiourea
Thiourea, N-ethyl-
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
161.6±23.0 °C at 760 mmHg
[ Melting Point ]:
108-110 °C(lit.)
[ Molecular Formula ]:
C3H8N2S
[ Molecular Weight ]:
104.174
[ Flash Point ]:
51.5±22.6 °C
[ Exact Mass ]:
104.040817
[ PSA ]:
70.14000
[ LogP ]:
-0.18
[ Vapour Pressure ]:
2.3±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.549
[ Storage condition ]:
Store at RT
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YT3700000
- CHEMICAL NAME :
- Urea, 1-ethyl-2-thio-
- CAS REGISTRY NUMBER :
- 625-53-6
- BEILSTEIN REFERENCE NO. :
- 1699551
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C3-H8-N2-S
- MOLECULAR WEIGHT :
- 104.19
- WISWESSER LINE NOTATION :
- SUYZM2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 500 mg/kg
- SEX/DURATION :
- female 12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1 gm/kg
- SEX/DURATION :
- female 12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - gastrointestinal system Reproductive - Specific Developmental Abnormalities - urogenital system
MUTATION DATA
- TYPE OF TEST :
- DNA repair
- TEST SYSTEM :
- Microorganism - not otherwise specified
- DOSE/DURATION :
- 10 mg/plate
- REFERENCE :
- BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1881- Volume(issue)/page/year: 95,463,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4672 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1031 (estimated) No. of Female Employees: 449 (estimated)
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301
[ Precautionary Statements ]:
P301 + P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ Hazard Codes ]:
T
[ Risk Phrases ]:
25
[ Safety Phrases ]:
S36/37/39-S45
[ RIDADR ]:
UN 2811 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
YT3700000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Dalton Trans. 39(18) , 4391-404, (2010)
Syntheses, single crystal X-ray structural and spectroscopic characterizations are described for a variety of adducts of silver halides with thiourea ('tu'), N-ethylthiourea ('ettu' = EtNH.CS.NH(2)) a...
Infrared spectra of new Re(III) complexes with thiourea derivatives.Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 58(14) , 3085-92, (2002)
Complexes of the type [Re(III)L6]X3, with L = thiourea, N-methylthiourea, N-ethylthiourea or N,N'-dimethytlthiourea and X = Cl- or PF6-, were prepared as suitable precursors for the synthesis of new r...
A convenient protocol for selective cleavage of 2-hydroxy acid amides. Application to semisynthesis of the cyclic heptapeptide aza HUN-7293.J. Org. Chem. 67(24) , 8299-304, (2002)
A two-step protocol for the first chemoselective cleavage of 2-hydroxy acid amides has been developed. Mesylation of the model substrate 2-(hydroxypropionylamino)-4-methylpentanoic acid methyl ester (...