JYL-1511

Names

[ Name ]:
JYL-1511

[Synonym ]:
JYL-1511
Methanesulfonamide,N-(4-((((((4-(1,1-dimethylethyl)phenyl)methyl)amino)thioxomethyl)amino)methyl)-2-methoxyphenyl)
thiourea analogue,3
UNII-9MD3654O9N

Biological Activity

[Description]:

JYL 1511 is a partial agonist of vanilloid receptor VR1[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Inflammation/Immunology

[In Vitro]

JYL 1511 抑制 [3H]Resiniferatoxin 与大鼠 VR1 的结合，Ki 为 50.4 nM[1]。 JYL 1511 抑制过表达大鼠 VR1 的 CHO 细胞中辣椒素诱导的 45Ca2+ 摄取 (IC50: 3.4 nM)[1].

[References]

[1]. Wang Y, et al. High-affinity partial agonists of the vanilloid receptor. Mol Pharmacol. 2003 Aug;64(2):325-33.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₉N₃O₃S₂

[ Molecular Weight ]:
435.60

[ Exact Mass ]:
435.16500

[ PSA ]:
119.93000

[ LogP ]:
5.46410

Related Compounds

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