4-(tert-Butyl)-benzhydroxamic Acid

Names

[ CAS No. ]:
62034-73-5

[ Name ]:
4-(tert-Butyl)-benzhydroxamic Acid

[Synonym ]:
p-tert-butyl benzohydroxamic acid

Biological Activity

[Description]:

4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively. 4-(tert-Butyl)-benzhydroxamic Acid reduces the production of the virulence factor pyocyanin in P. aeruginosa with an IC50 of 87.2 μM[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 12.5 μM (PqsR in E. coli), 23.6 μM (PqsR in P. aeruginosa), 87.2 μM (virulence factor pyocyanin)[1]

[References]

[1]. Klein T, et al. Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptionalregulator PqsR: biophysically guided hit discovery and optimization. ACS Chem Biol. 2012 Sep 21;7(9):1496-501.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₅NO₂

[ Molecular Weight ]:
193.24

[ Exact Mass ]:
193.11000

[ PSA ]:
49.33000

[ LogP ]:
2.49400

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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