phosphocyclocreatine

Names

[ Name ]:
phosphocyclocreatine

[Synonym ]:
Phosphocyclocreatine
N-Phosphorylcyclocreatine
[(2e)-2-imino-3-phosphonoimidazolidin-1-yl]acetic acid
Cyclocreatine phosphate

Biological Activity

[Description]:

Cyclocreatine phosphate is an anti-tumor agent. Cyclocreatine phosphate is the proposed active form of cyclocreatine (CCr), a substrate analogue of creatine kinase. Cyclocreatine phosphate has anti-tumour activity and can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vivo]

Cyclocreatine phosphate (CCr'P) (i.p.; 37.5 mg/mL; 0.2 mL, twice daily) has anti-tumor activity without any notable signs of toxicity in a mouse xenograft model for human prostate cancer[1]. Animal Model: Athymic (CDl-Nu/Nu) male mice[1] Dosage: 37.5 mg/mL Administration: intraperitoneally , 0.2 mL, twice daily Result: Showed anti-tumor effect.

[References]

[1]. Rima Kaddurah-Daouk, et al. Creatine phosphate, creatine phosphate analogs, and uses therefor. Patent. WO1994016712A1.

Chemical & Physical Properties

[ Density]:
2.03g/cm3

[ Boiling Point ]:
481ºC at 760 mmHg

[ Molecular Formula ]:
C₅H₁₀N₃O₅P

[ Molecular Weight ]:
223.12400

[ Flash Point ]:
244.7ºC

[ Exact Mass ]:
223.03600

[ PSA ]:
134.97000

[ Index of Refraction ]:
1.733