TRIPELENNAMINE CITRATE

Names

[ CAS No. ]:
6138-56-3

[ Name ]:
TRIPELENNAMINE CITRATE

[Synonym ]:
Pyridine,2-(benzyl(2-(dimethylamino)ethyl)amino)-,citrate (1:1)
Pyribenzamine citrate
EINECS 228-121-6
Tripelennamine citrate
1,2-Ethanediamine,N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-,2-hydroxy-1,2,3-propanetricarboxylate (1:1)

Biological Activity

[Description]:

Tripelennamine citrate, an ethylenediamine derivative, is a potent histamine H1-receptor antagonist. Tripelennamine citrate lessens the allergic response of the organism caused by histamine. Tripelennamine citrate can be used for the research of rhinitis, conjunctivitis, and allergic and anaphylactic reactions[1][2][3].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Research Areas >> Endocrinology
Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

H1 Receptor


[References]

[1]. Manohar M, et al. H1-receptor antagonist, tripelennamine, does not affect arterial hypoxemia in exercising Thoroughbreds. J Appl Physiol. 2002 Apr;92(4):1515-23.

[2]. Wasfi IA, et al. Comparative disposition of tripelennamine in horses and camels after intravenous administration. J Vet Pharmacol Ther. 2000 Jun;23(3):145-52.

[3]. Yeh SY, et al. The pharmacokinetics of pentazocine and tripelennamine. Clin Pharmacol Ther. 1986 Jun;39(6):669-76.

Chemical & Physical Properties

[ Boiling Point ]:
387.8ºC at 760 mmHg

[ Melting Point ]:
106-110°

[ Molecular Formula ]:
C22H29N3O7

[ Molecular Weight ]:
447.48200

[ Flash Point ]:
188.3ºC

[ Exact Mass ]:
447.20100

[ PSA ]:
151.50000

[ LogP ]:
1.40130

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US2950000
CAS REGISTRY NUMBER :
6138-56-3
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C16-H21-N3.C6-H8-O7
MOLECULAR WEIGHT :
447.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
6168 ug/kg/12H
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 16,331,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80566 No. of Facilities: 460 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 3946 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80566 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1957 (estimated) No. of Female Employees: 1888 (estimated)

Safety Information

[ RIDADR ]:
UN 3249

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.