4-Nitro-1-naphthol

Names

[ CAS No. ]:
605-62-9

[ Name ]:
4-Nitro-1-naphthol

[Synonym ]:
4-nitronaphthalen-1-ol
1-Naphthalenol, 4-nitro-
MFCD02179392
4-Nitro-1-naphthol

Biological Activity

[Description]:

KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor, with IC50s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

IC50: 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B)[1]

[In Vitro]

KAT8-IN-1 (compound 19) losses anti-oxidant activity (EC50>1 mM)[1].

[References]

[1]. Wapenaar H, et al. The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. Eur J Med Chem. 2017 Aug 18;136:480-486.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
398.8±25.0 °C at 760 mmHg

[ Melting Point ]:
165-168°C

[ Molecular Formula ]:
C₁₀H₇NO₃

[ Molecular Weight ]:
189.167

[ Flash Point ]:
179.8±11.6 °C

[ Exact Mass ]:
189.042587

[ PSA ]:
66.05000

[ LogP ]:
2.80

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.714

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
2811

[ HS Code ]:
2908999090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2908999090

[ Summary ]:
2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%