2-(1-Methylguanidino)acetic acid hydrate

Names

[ Name ]:
2-(1-Methylguanidino)acetic acid hydrate

[Synonym ]:
Glycine, N-(aminoiminomethyl)-N-methyl-, hydrate (1:1)
N-Carbamimidoyl-N-methylglycine hydrate (1:1)
Creatine, hydrate
MFCD00071582
EINECS 200-306-6
Creatine monohydrate
2-[carbamimidoyl(methyl)amino]acetic acid,hydrate

Biological Activity

[Description]:

Creatine monohydrate, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite

[References]

[1]. Nouioua S, et al. Creatine deficiency syndrome. A treatable myopathy due to arginine-glycine amidinotransferase (AGAT) deficiency. Neuromuscul Disord. 2013 Aug;23(8):670-4.

Chemical & Physical Properties

[ Melting Point ]:
292 °C (dec.)(lit.)

[ Molecular Formula ]:
C₄H₁₁N₃O₃

[ Molecular Weight ]:
149.148

[ Exact Mass ]:
149.080048

[ PSA ]:
99.64000

[ Storage condition ]:
Store at RT.

[ Water Solubility ]:
13 g/L (20 ºC)

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi,Xn

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
MB7706000

[ HS Code ]:
29252000

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

In-line coupling of single-drop microextraction with capillary electrophoresis-mass spectrometry.

Anal. Bioanal. Chem 407 , 8745-52, (2015)

Single-drop microextraction (SDME) was in-line coupled with capillary electrophoresis-mass spectrometry to provide sample cleanup and enrichment simultaneously. Since there is no outlet vial in a conv...

Creatine is a scavenger for methylglyoxal under physiological conditions via formation of N-(4-methyl-5-oxo-1-imidazolin-2-yl)sarcosine (MG-HCr).

J. Agric. Food Chem. 63(8) , 2249-56, (2015)

Following incubation of methylglyoxal and creatine under physiological conditions, N-(4-methyl-5-oxo-1-imidazolin-2-yl)sarcosine (MG-HCr) was isolated and identified by NMR and mass spectrometry. Due ...

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart.

PLoS ONE 9(10) , e109021, (2014)

Multiple studies suggest creatine mediates anti-oxidant activity in addition to its established role in cellular energy metabolism. The functional significance for the heart has yet to be established,...

Related Compounds

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