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Arecaidine Hydrobromide

Names

[ CAS No. ]:
6013-57-6

[ Name ]:
Arecaidine Hydrobromide

[Synonym ]:
1-methyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid,hydrobromide
Nicotinic acid,1,2,5,6-tetrahydro-1-methyl-,hydrobromide
3-Pyridinecarboxylic acid,1,2,5,6-tetrahydro-1-methyl-,hydrobromide
1-Methyl-1,2,5,6-tetrahydro-pyridin-3-carbonsaeure,Hydrochlorid
1-Methyl-1,2,5,6-tetrahydro-pyridin-3-carbonsaeure,Hydrobromid
Nicotinic acid,1,2,5,6-tetrahydro-1-methyl-,hydrobromide (8CI)
1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid hydrobromide
1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic acid hydrobromide
Arecaidine hydrobromide

Biological Activity

[Description]:

Arecaidine hydrobromide, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrobromide is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[References]

[1]. D Lodge, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136(3):513-22.  

[2]. Valerie Voigt, et al. Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1). J Pharm Pharmacol. 2013 Apr;65(4):582-90.  

Chemical & Physical Properties

[ Boiling Point ]:
266.7ºC at 760 mmHg

[ Molecular Formula ]:
C7H12BrNO2

[ Molecular Weight ]:
222.08

[ Flash Point ]:
115.1ºC

[ Exact Mass ]:
221.00500

[ PSA ]:
40.54000

[ LogP ]:
1.22890

Synthetic Route

Click to get detail synthetic route

Related Compounds