UK-500001

Names

[ Name ]:
UK-500001

[Synonym ]:
2-(3,4-Difluorophenoxy)-5-fluoro-N-{cis-4-[(2-hydroxy-5-methylbenzoyl)amino]cyclohexyl}nicotinamide
3-Pyridinecarboxamide, 2-(3,4-difluorophenoxy)-5-fluoro-N-[cis-4-[(2-hydroxy-5-methylbenzoyl)amino]cyclohexyl]-
YOG0PR3Q8J
UK-500001

Biological Activity

[Description]:

A potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 26.1, 22.8, 21 and 0.28 nM for PDE4A4, PDE4B2, PDE4C2 and PDE4D3, respectively.

[References]

References 1. Moretto N, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):559-67. 2. Vestbo J, et al. Eur Respir J. 2009 May;33(5):1039-44. View Related Products by Target Phosphodiesterase (PDE)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
632.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₂₄F₃N₃O₄

[ Molecular Weight ]:
499.482

[ Flash Point ]:
336.1±31.5 °C

[ Exact Mass ]:
499.171906

[ LogP ]:
5.12

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.619

Related Compounds

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