11-Maleimidoundecanoic acid

Names

[ Name ]:
11-Maleimidoundecanoic acid

[Synonym ]:
11-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)undecanoic acid
11-maleimido-undecanoic acid
1H-Pyrrole-1-undecanoic acid, 2,5-dihydro-2,5-dioxo-
UNII-LG78EY7HVB
maleimidoundecanoic acid

Biological Activity

[Description]:

11-Maleimidoundecanoic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
452.8±18.0 °C at 760 mmHg

[ Melting Point ]:
89-90ºC

[ Molecular Formula ]:
C₁₅H₂₃NO₄

[ Molecular Weight ]:
281.347

[ Flash Point ]:
227.6±21.2 °C

[ Exact Mass ]:
281.162720

[ PSA ]:
74.68000

[ LogP ]:
3.36

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.515

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2925190090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Synthesis of Heterotelechelic Polymers for Conjugation of Two Different Proteins.

Macromolecules 42 , 2360, (2009)

In this report we describe a straightforward approach to synthesize polymers with end-groups that bind site-specifically to two different proteins. Telechelic biotin, maleimide poly(N-isopropylacrylam...

Safak, M.; Alemdaroglu, F. E.; Li, Y.; Ergen, E.; Hernnann, A.

Adv. Mater. 19 , 1499, (2007)