Batatasin III

Names

[ Name ]:
Batatasin III

[Synonym ]:
3-Ethyl-1-<2-(3-indolyl)-ethyl>-piperidin
3-[2-(3-ethyl-piperidin-1-yl)-ethyl]-indole
batatatsin III
batatasin III
1-<2-(3-indolyl)ethyl>-3-ethylpiperidine
1H-Indole,3-[2-(3-ethyl-1-piperidinyl)ethyl]
3,3'-dihydroxy-5-methoxybibenzyl
3-[2-(3-hydroxyphenyl)ethyl]-5-methoxyphenol
Batatasin Ⅲ

Biological Activity

[Description]:

Batatasin III, a stilbenoid, inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition (EMT) and FAK-AKT Signals. Batatasin III has anti-cancer activities[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FAK

Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[Target]

Akt

[In Vitro]

Batatasin III (25-100 μM; 48 h) exhibits anti-proliferative activity in H460 cells. Batatasin III at concentrations lower than 100 μM has no cytotoxic effects[1]. Batatasin III significantly suppresses EMT indicated by the decrease of N-cadherin and Vimentin, and up-regulation of E-cadherin[1].

[References]

[1]. Tatchakorn Pinkhien, et al. Batatasin III Inhibits Migration of Human Lung Cancer Cells by Suppressing Epithelial to Mesenchymal Transition and FAK-AKT Signals. Anticancer Res. 2017 Nov;37(11):6281-6289.

Chemical & Physical Properties

[ Density]:
1.126g/cm3

[ Boiling Point ]:
406.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₈O₃

[ Molecular Weight ]:
258.31200

[ Flash Point ]:
199.4ºC

[ Exact Mass ]:
258.12600

[ PSA ]:
38.69000

[ LogP ]:
3.19460

[ Index of Refraction ]:
1.572

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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