Tibolone(Liviella)(Livial)

Names

[ Name ]:
Tibolone(Liviella)(Livial)

[Synonym ]:
EINECS 227-069-1
17-Hydroxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-3-one
Tibolone
7a-Methyl-5,10-norethindrone
7a-Methyl-17a-ethynyl-17b-hydroxy-19-norandrost-5(10)-en-3-one
LIVIELLA
19-Norpregn-5(10)-en-20-yn-3-one, 17-hydroxy-7-methyl-, (7α,17α)-
Org OD 14
(7α,17α)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one
7a-Methyl-D5,10-norethindrone
(7R,8R,9S,13S,14S,17R)-17-Ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
Estr-5(10)-en-3-one, 17-ethynyl-17-hydroxy-7-methyl-, (7α,17β)-
Livial
7a-Methyl-17a-ethynyl-17b-hydroxyestr-5(10)-en-3-one
MFCD00864178
(7a,17a)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one

Biological Activity

[Description]:

Tibolone is a broad spectrum gonadal steroid agonist with progestagenic, androgenic, and estrogenic activities. Tibolone can be used for postmenopausal osteoporosis research[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Signaling Pathways >> Others >> Progesterone Receptor

Research Areas >> Endocrinology

Signaling Pathways >> Others >> Androgen Receptor

[In Vivo]

Tibolone (1 mg/day; oral administration; for 12 weeks) treatment enhances the osseointegration process of intramedullary titanium implants in ovariectomized rats[1]. Animal Model: Female albino Wistar rats bearing ovariectomy[1] Dosage: 1 mg/day Administration: Oral administration; daily; for 12 weeks Result: Showed a significantly higher overall bone tissue and a higher body mass density.

[References]

[1]. Dragos Apostu, et al. Tibolone, alendronate, and simvastatin enhance implant osseointegration in a preclinical in vivo model. Clin Oral Implants Res. 2020 Jul;31(7):655-668.

[2]. Marcos García-Juárez, et al. Tibolone induces lordosis behavior, but not concurrent or sequential inhibition, in Sprague Dawley rats. Neurosci Lett. 2021 Apr 24;755:135916.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
447.4±45.0 °C at 760 mmHg

[ Melting Point ]:
169 °C

[ Molecular Formula ]:
C₂₁H₂₈O₂

[ Molecular Weight ]:
312.446

[ Flash Point ]:
190.6±21.3 °C

[ Exact Mass ]:
312.208923

[ PSA ]:
37.30000

[ LogP ]:
4.03

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.570

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
N

[ Risk Phrases ]:
R51/53

[ Safety Phrases ]:
S22-S24/25-S61

[ RIDADR ]:
UN 3077 9/PG 3

[ RTECS ]:
RC8964020

Precursor & DownStream

Precursor

DownStream

Articles

Tibolone prevents oxidation and ameliorates cholinergic deficit induced by ozone exposure in the male rat hippocampus.

Neurochem. Res. 39(9) , 1776-86, (2014)

Oxidative stress is related to the development of central nervous system diseases involving memory processes. Cholinergic system and memory processes are disrupted by ozone exposure. In rats, ozone in...

Effects of tibolone or continuous combined oestradiol/norethisterone acetate on glucose and insulin metabolism.

Clin. Endocrinol. (Oxf.) 78(2) , 297-302, (2013)

To determine the effects of tibolone or oestradiol (E(2) )/norethisterone acetate (NETA) hormone replacement therapy on glucose and insulin metabolism in postmenopausal women.Single-centre double-blin...

Effects of a continuous-combined regimen of low-dose hormone therapy (oestradiol and norethindrone acetate) and tibolone on the quality of life in symptomatic postmenopausal women: a double-blind, randomised study.

Maturitas 74(2) , 172-8, (2013)

This study compared the effects of a continuous-combined regimen of low-dose hormone therapy (LD-HT) versus tibolone and supplemental calcium/vitamin D3 (control) on quality of life (QoL) in symptomat...

Related Compounds

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