4-Nitroquinoline 1-oxide

Names

[ CAS No. ]:
56-57-5

[ Name ]:
4-Nitroquinoline 1-oxide

[Synonym ]:
EINECS 200-281-1
MFCD00006738
4-nitro-1-oxidoquinolin-1-ium
4-nitroquinoline-N-oxide
Quinoline, 4-nitro-, 1-oxide
4-Nitroquinoline 1-oxide
4-nitroquinoline n-oxide

Biological Activity

[Description]:

Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells. Nitrochin induces DNA damage, and induces apoptosis via a p53-dependent mitochondrial signaling pathway[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Mukherjee A, et al. Carcinogen 4-Nitroquinoline Oxide (4-NQO) Induces Oncostatin-M (OSM) in Esophageal Cells. In Vivo. 2023 Mar-Apr;37(2):506-518.

[2]. Han H, et al. 4-NQO induces apoptosis via p53-dependent mitochondrial signaling pathway. Toxicology. 2007 Feb 12;230(2-3):151-63.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
387.6±34.0 °C at 760 mmHg

[ Melting Point ]:
154-156 °C(lit.)

[ Molecular Formula ]:
C₉H₆N₂O₃

[ Molecular Weight ]:
190.16

[ Flash Point ]:
188.2±25.7 °C

[ Exact Mass ]:
190.037842

[ PSA ]:
71.28000

[ LogP ]:
0.92

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.659

[ Storage condition ]:
−20°C

[ Stability ]:
Stable. Hygroscopic, light-sensitive. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
acetone: clear to hazy

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H350

[ Precautionary Statements ]:
P201-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R33

[ Safety Phrases ]:
S53-S45

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ RTECS ]:
VC2100000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

Precursor & DownStream

Precursor

DownStream

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