D-Thr-OH

Names

[ CAS No. ]:
556-02-5

[ Name ]:
D-Thr-OH

[Synonym ]:
L-tyrosine zwitterion
hydrogen L-tyrosinate
MFCD00063073
(2R)-2-amino-3-(4-hydroxyphenyl)propanoic acid
a-Amino-p-hydroxyhydrocinnamic Acid
L-Phenylalanine, 4-hydroxy-
D-p-Tyrosine
EINECS 209-112-6
d-Tyr
Tyrosine, d-
H-Tyr-OH
Tyrosine
(R)-Tyrosine
L-Tyr
H-D-Tyr-OH
Tyr
(S)-(-)-Tyrosine
(S)-a-Amino-4-hydroxybenzenepropanoic acid
Tyrosine, L-
b-(p-Hydroxyphenyl)alanine
hydrogen D-tyrosinate
Benzenepropanoic acid, α-amino-4-hydroxy-, (S)-
Tyrosinum [Latin]
(S)-a-amino-4-hydroxy-Benzenepropanoic acid
(S)-tyrosine
(S)-α-amino-4-hydroxy-Benzenepropanoic acid
DL-tyrosine
D-Thr-OH

Biological Activity

[Description]:

D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

Research Areas >> Metabolic Disease

[Target]

Tyrosinase[1]

[References]

[1]. Jisu Park, et al. D-tyrosine Negatively Regulates Melanin Synthesis by Competitively Inhibiting Tyrosinase Activity. Pigment Cell Melanoma Res. 2018 May;31(3):374-383.

[2]. Cong Yu, et al. Inhibition of Biofilm Formation by D-tyrosine: Effect of Bacterial Type and D-tyrosine Concentration. Water Res. 2016 Apr 1;92:173-9.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
385.2±32.0 °C at 760 mmHg

[ Melting Point ]:
310-314ºC

[ Molecular Formula ]:
C₉H₁₁NO₃

[ Molecular Weight ]:
181.189

[ Flash Point ]:
186.7±25.1 °C

[ Exact Mass ]:
181.073898

[ PSA ]:
83.55000

[ LogP ]:
0.38

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.614

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids.

Bioorg. Med. Chem. Lett. 20 , 1701-4, (2010)

The protein encoded by the NCE103 gene of Candida glabrata, a beta-carbonic anhydrase (CA, EC 4.2.1.1) designated as CgCA, was investigated for its activation with amines and amino acids. CgCA was wea...