(15S,16E)-16,17,20,21-Tetradehydro-16-formyl-18,19-secoyohimban-19-oic acid methyl ester

Names

[ CAS No. ]:
5523-37-5

[ Name ]:
(15S,16E)-16,17,20,21-Tetradehydro-16-formyl-18,19-secoyohimban-19-oic acid methyl ester

[Synonym ]:
18,19-Secoyohimban-19-oic acid,16,17,20,21-tetradehydro-16-formyl-,methyl ester,(15beta,16E)

Biological Activity

[Description]:

Vallesiachotamine, a known monoterpene indole alkaloid, possesses anti-tumor activity[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[In Vitro]

Vallesiachotamine induces G0/G1 arrest and increased the proportion of sub-G1 hypodiploid cells (at 11 μM and 22 μM) and this effect is not dependent on time of incubation. Vallesiachotamine acts by promoting G0/G1 cell cycle arrest, apoptosis and necrosis[1].

[References]

[1]. Paula R O Soares, et al. In vitro antiproliferative effects of the indole alkaloid vallesiachotamine on human melanoma cells. Paula R O Soares. 2012 Mar;35(3):565-71.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₂N₂O₃

[ Molecular Weight ]:
350.41

[ Exact Mass ]:
350.16300

[ PSA ]:
62.40000

[ LogP ]:
3.22700

Related Compounds

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