10β,17β-dihydroxyestra-1,4-dien-3-one

Names

[ CAS No. ]:
549-02-0

[ Name ]:
10β,17β-dihydroxyestra-1,4-dien-3-one

[Synonym ]:
DHED

Biological Activity

[Description]:

10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain[1].

[In Vivo]

10β,17β-dihydroxyestra-1,4-dien-3-one (DHED), is an inactive bioprecursor prodrug of 17β-estradiol converting to 17β-estradiol only in the brain. DHED as an E2-bioprecursor may be a viable approach for delivering E2 selectively into the brain for the potential treatment of hot flushes[1].

[References]

[1]. Merchenthaler I, et al. Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery. Sci Rep. 2016 Aug 1;6:30721.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
485.3±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₄O₃

[ Molecular Weight ]:
288.381

[ Flash Point ]:
261.4±25.2 °C

[ Exact Mass ]:
288.172546

[ LogP ]:
1.82

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.607

Related Compounds

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