Trihydroxycholestanoic Acid

Names

[ CAS No. ]:
547-98-8

[ Name ]:
Trihydroxycholestanoic Acid

[Synonym ]:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oic acid
Trihydroxycholestanoic acid

Biological Activity

[Description]:

Trihydroxycholestanoic acid is an endogenous metabolite present in Blood that can be used for the research of Zellweger Syndrome, Refsum Disease, D Bifunctional Protein Deficiency and Infantile Refsum Disease[1][2][3][4].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[In Vitro]

Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].

[References]

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

[2]. Baumgartner MR, et al. Clinical approach to inherited peroxisomal disorders: a series of 27 patients. Ann Neurol. 1998 Nov;44(5):720-30.

[3]. Poll-The BT, et al. Infantile Refsum's disease: biochemical findings suggesting multiple peroxisomal dysfunction. J Inherit Metab Dis. 1986;9(2):169-74.

[4]. Rizzo C, et al. Characteristic acylcarnitine profiles in inherited defects of peroxisome biogenesis: a novel tool for screening diagnosis using tandem mass spectrometry. Pediatr Res. 2003 Jun;53(6):1013-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₄₆O₅

[ Molecular Weight ]:
450.65100

[ Exact Mass ]:
450.33500

[ PSA ]:
97.99000

[ LogP ]:
4.47490

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.