S-(LACTOYL)GLUTATHIONE

Names

[ Name ]:
S-(LACTOYL)GLUTATHIONE

[Synonym ]:
MFCD00058432
s-(lactoyl)glutathione

Biological Activity

[Description]:

S-lactoylglutathione is a serum metabolite and can be used as a potential marker for sensitivity of gastric cancer to neoadjuvant chemotherapy[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Daguang Wang, et al. Association of serum levels of deoxyribose 1-phosphate and S-lactoylglutathione with neoadjuvant chemotherapy sensitivity in patients with gastric cancer: A metabolomics study. Oncol Lett. 2020 Mar;19(3):2231-2242.

Chemical & Physical Properties

[ Density]:
1.469g/cm3

[ Boiling Point ]:
772.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₉N₃O₈S

[ Molecular Weight ]:
377.37

[ Flash Point ]:
420.8ºC

[ Exact Mass ]:
379.10500

[ PSA ]:
221.42000

[ Index of Refraction ]:
1.569

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
22-26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0

Articles

Sciadopitysin alleviates methylglyoxal-mediated glycation in osteoblastic MC3T3-E1 cells by enhancing glyoxalase system and mitochondrial biogenesis.

Free Radic. Res. 48(7) , 729-39, (2014)

Methylglyoxal (MG) is a precursor of advanced glycation end products, which contribute to diabetic complications, including bone defects. In the present study, the effect of sciadopitysin on MG-induce...

Converting GLX2-1 into an active glyoxalase II.

Biochemistry 49 , 8228-8236, (2010)

Arabidopsis thaliana glyoxalase 2-1 (GLX2-1) exhibits extensive sequence similarity with GLX2 enzymes but is catalytically inactive with SLG, the GLX2 substrate. In an effort to identify residues esse...

The binding of iron and zinc to glyoxalase II occurs exclusively as di-metal centers and is unique within the metallo-beta-lactamase family.

J. Biol. Inorg. Chem. 9 , 429-438, (2004)

Cytosolic glyoxalase 2 (GLX2-2) from Arabidopsis thaliana is a metalloenzyme that has been shown to bind a mixture of Zn, Fe, or Mn when produced in cells grown in rich media. In an effort to prepare ...