Fmoc-leucine-d3

Names

[ Name ]:
Fmoc-leucine-d3

[Synonym ]:
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-(5',5',5'-H)leucine
L-Leucine-5',5',5'-d, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

Biological Activity

[Description]:

Fmoc-leucine-d3 is the deuterium labeled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice. Fmoc-leucine has a lower adipogenic activity[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Rocchi S, et al. A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell. 2001 Oct;8(4):737-47.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
559.8±33.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₀D₃NO₄

[ Molecular Weight ]:
356.43

[ Flash Point ]:
292.4±25.4 °C

[ Exact Mass ]:
356.181549

[ PSA ]:
75.63000

[ LogP ]:
4.95

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.583

[ Storage condition ]:
2-8°C

Related Compounds

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