ar-Turmerone

Names

[ CAS No. ]:
532-65-0

[ Name ]:
ar-Turmerone

[Synonym ]:
Tumerone
(+)-ar-Turmerone
(S)-AR-TURMERONE

Biological Activity

[Description]:

ar-Turmerone ((+)-ar-Turmerone) is a major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities[1][2][3]. ar-turmerone ((+)-ar-Turmerone) activates apoptotic protein in human lymphoma U937 cells[3]. ar-Turmerone ((+)-ar-Turmerone) exerts positive modulation on murine DCs, induces NSC proliferation and constitutes a promising therapeutic agent for various neurologic disorders[4][5].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[References]

[1]. Liju VB, et al. An evaluation of antioxidant, anti-inflammatory, and antinociceptive activities of essential oil from Curcuma longa. L. Indian J Pharmacol. 2011 Sep;43(5):526-31.

[2]. Yue GG, et al. Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa. Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2011-20.

[3]. Lee Y, et al. Activation of apoptotic protein in U937 cells by a component of turmeric oil. BMB Rep. 2009 Feb 28;42(2):96-100.

[4]. Yonggang T, et al. Maturation and upregulation of functions of murine dendritic cells (DCs) under the influence of purified aromatic-turmerone (AR). Hum Vaccin Immunother. 2012 Oct;8(10):1416-24.

[5]. Hucklenbroich J, et al. Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo. Stem Cell Res Ther. 2014 Sep 26;5(4):100.

Chemical & Physical Properties

[ Boiling Point ]:
326℃

[ Molecular Formula ]:
C₁₅H₂₀O

[ Molecular Weight ]:
216.31900

[ Exact Mass ]:
216.15100

[ PSA ]:
17.07000

[ LogP ]:
4.02390

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317-H319-H411

[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338

[ Hazard Codes ]:
Xi,N

[ Risk Phrases ]:
36-43-51/53

[ Safety Phrases ]:
36/37-61

[ RIDADR ]:
UN 3082 9 / PGIII

[ HS Code ]:
2914399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914399090

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Turmeric (Curcuma longa L.) volatile oil inhibits key enzymes linked to type 2 diabetes.

Int. J. Food Sci. Nutr. 63(7) , 832-4, (2012)

Anti-diabetic capacity of Curcuma longa volatile oil in terms of its ability to inhibit glucosidase activities was evaluated. Turmeric volatile oils inhibited glucosidase enzymes more effectively than...

Selective induction of apoptosis by ar-turmerone isolated from turmeric (Curcuma longa L) in two human leukemia cell lines, but not in human stomach cancer cell line.

Int. J. Mol. Med. 9(5) , 481-4, (2002)

We have investigated the effects of ar-turmerone isolated from turmeric (Curcuma longa L) on DNA of human leukemia cell lines, Molt 4B, HL-60 and stomach cancer KATO III cells. It was found that selec...

Induction of apoptosis by ar-turmerone on various cell lines.

Int. J. Mol. Med. 14(2) , 253-6, (2004)

This study investigated the cytotoxic effect of ar-turmerone isolated from turmeric (Curcuma longa L) on the K562, L1210, U937 and RBL-2H3 cell lines by the MTT assay. Ar-turmerone exhibited potent cy...