adrenaline sulfate

Adrenaline sulfate is a orally active hormone secreted by the medulla of the adrenal glands. Adrenaline sulfate is an α-adrenergic and β-adrenergic receptor agonist. Adrenaline sulfate can be used in the treatment of anaphylaxis. Adrenaline sulfate has the potential for the research of cardiac arrest[1][2][3][4].

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Neurological Disease

Human Endogenous Metabolite

Adrenaline sulfate (0.75, 1.5, 3 mg/kg; i.p.) exerts oxidative and nitrative stress in rats, increased damage to lipids and proteins, and damage of cardiomyocytes and cytogenetic damage in rats[2]. Adrenaline sulfate (0.02, 0.03 mg/kg) increases ABP’s and to some extent also CePP, but significantly decreases organ and brain perfusion in adult pigs[3]. Adrenaline sulfate (0.1 mg/kg; s.c.) enhances memory in young adult rats, in part, by increasing blood glucose levels needed to modulate memory[6]. Animal Model: 220-280 g, 18 weeks Wistar rats[2] Dosage: 0.75, 1.5, 3 mg/kg Administration: IP Result: Induced a significant rise in CAT activity, MDA level, PCC, NO2−, and 3-NT and a significant decrease in SOD activity, and exerted an increase in total activity of LDH, LDH1, and LDH2 isoenzymes. Animal Model: 24-25 month male Fischer-344 rats[6] Dosage: 0.1 mg/kg Administration: S.c. Result: Enhanced memory in young adult rats, in part, by increasing blood glucose levels needed to modulate memory.

[1]. McLean-Tooke AP, et al. Adrenaline in the treatment of anaphylaxis: what is the evidence? BMJ. 2003 Dec 6;327(7427):1332-5.

[2]. Radaković M, et al. Nitroso-Oxidative Stress, Acute Phase Response, and Cytogenetic Damage in Wistar Rats Treated with Adrenaline. Oxid Med Cell Longev. 2018 Nov 21;2018:1805354.

[3]. Hardig BM, et al. Physiologic effect of repeated adrenaline (epinephrine) doses during cardiopulmonary resuscitation in the cath lab setting: A randomised porcine study. Resuscitation. 2016 Apr;101:77-83.

[4]. Callaway CW. Epinephrine for cardiac arrest. Curr Opin Cardiol. 2013 Jan;28(1):36-42.

[5]. Simons FE, et al. First-aid treatment of anaphylaxis to food: focus on epinephrine. J Allergy Clin Immunol. 2004 May;113(5):837-44.

[6]. Morris KA, et al. Epinephrine and glucose modulate training-related CREB phosphorylation in old rats: relationships to age-related memory impairments. Exp Gerontol. 2013 Feb;48(2):115-27.