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Oxeladin (citrate)

Names

[ CAS No. ]:
52432-72-1

[ Name ]:
Oxeladin (citrate)

[Synonym ]:
Bio-0361
HMS3264M05
Oxeladin citrate salt
oxeladin dihydrogen citrate
oxeladin citrate
Oxeladin-zitrat
Oxeladin (citrate)

Biological Activity

[Description]:

Oxeladin citrate is a cough suppressant, is a highly potent and effective drug used to treat all types of cough of various etiologies.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Boiling Point ]:
609.1ºC at 760 mmHg

[ Melting Point ]:
90-91°

[ Molecular Formula ]:
C26H41NO10

[ Molecular Weight ]:
527.60400

[ Flash Point ]:
322.2ºC

[ Exact Mass ]:
527.27300

[ PSA ]:
170.90000

[ LogP ]:
2.39750

[ Storage condition ]:
-20℃

[ Water Solubility ]:
Freely soluble in water, slightly to very slightly soluble in ethyl acetate.

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ET1760000
CHEMICAL NAME :
Butyric acid, 2-ethyl-2-phenyl-, 2-(2-(diethylamino)ethoxy)ethyl ester, citrate
CAS REGISTRY NUMBER :
52432-72-1
LAST UPDATED :
198910
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C20-H33-N-O3.C6-H8-O7
MOLECULAR WEIGHT :
527.68
WISWESSER LINE NOTATION :
2X2&R&VO2O2N2&2 &QV1XQVQ1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
183 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,157,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,157,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
244 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 82,1314,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
13 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,157,1982

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311 + H331

[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P261-P280-P302 + P352 + P312-P304 + P340 + P312-P403 + P233

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T

[ Risk Phrases ]:
23/24/25

[ Safety Phrases ]:
36/37/39-45

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
ET1760000

Articles

High performance liquid chromatographic determination of oxeladin citrate and oxybutynin hydrochloride and their degradation products.

Il Farmaco 60(8) , 689-99, (2005)

Two high performance liquid chromatographic (HPLC) methods are presented for the determination of oxeladin citrate (OL) and oxybutynin hydrochloride (OB) and their degradation products. The first meth...

Determination of oxeladin in human sera by gas--liquid chromatography with thermionic detection.

J. Chromatogr. A. 225(2) , 463-8, (1981)

[Determination of oxeladin citrate in drug combinations].

Pharmazie 37(1) , 76-7, (1982)


More Articles


Related Compounds