L-Glutamic acid,N-[4-[[(2-amino-3,4-dihydro-4-oxopyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-

Names

[ CAS No. ]:
51989-25-4

[ Name ]:
L-Glutamic acid,N-[4-[[(2-amino-3,4-dihydro-4-oxopyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-

[Synonym ]:
8-deazafolic acid

Biological Activity

[Description]:

8-Deazafolic acid is an antimicrobial drug for the folate-dependent bacteria, Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 74691). 8-Deazafolic acid has activity against lymphoid leukemia L1210 in mice[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Carroll Temple Jr, et al. New synthesis of N-[4-[[(2-amino-4(3H)-oxopyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamic acid (8-deazafolic acid) and the preparation of some 5,6,7,8-tetrahydro derivatives. J. Med. Chem. 1981, 24, 10, 1254–1258.

Chemical & Physical Properties

[ Density]:
1.61g/cm3

[ Molecular Formula ]:
C₂₀H₂₀N₆O₆

[ Molecular Weight ]:
440.40900

[ Exact Mass ]:
440.14400

[ PSA ]:
200.65000

[ LogP ]:
2.01760

[ Index of Refraction ]:
1.734

Related Compounds

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