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Mal-PEG3-Boc

Names

[ CAS No. ]:
518044-35-4

[ Name ]:
Mal-PEG3-Boc

[Synonym ]:
MAL-PEG2-CH2CH2COOTBU

Biological Activity

[Description]:

Mal-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
428.7±30.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H27NO7

[ Molecular Weight ]:
313.346

[ Flash Point ]:
213.1±24.6 °C

[ Exact Mass ]:
313.152527

[ LogP ]:
0.96

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.494

[ Storage condition ]:
2-8°C

Related Compounds