20(S)-Hydroxycholesterol
Names
[ CAS No. ]:
516-72-3
[ Name ]:
20(S)-Hydroxycholesterol
[Synonym ]:
20α-Hydroxy Cholesterol
20ALPHA-HYDROXYCHOLESTEROL
Biological Activity
[Description]:
[Related Catalog]:
[Target]
EC50: 3 μM (hedgehog signaling pathway)[1]
[References]
Chemical & Physical Properties
[ Density]:
1.03g/cm3
[ Boiling Point ]:
512.3ºC at 760mmHg
[ Melting Point ]:
136-137ºC
[ Molecular Formula ]:
C27H46O2
[ Molecular Weight ]:
402.65
[ Flash Point ]:
213.1ºC
[ Exact Mass ]:
402.35000
[ PSA ]:
40.46000
[ LogP ]:
6.50360
[ Index of Refraction ]:
1.538
[ Storage condition ]:
-20°C Freezer
MSDS
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Plast. Reconstr. Surg. 134(5) , 960-8, (2014)
Human adipose-derived stem cells have been identified as a potential source of cells for use in bone tissue engineering because of their ready availability, ease of harvest, and susceptibility to oste...
Conversion of exogenous cholesterol into glycoalkaloids in potato shoots, using two methods for sterol solubilisation.PLoS ONE 8 , e82955, (2013)
Steroidal glycoalkaloids (SGA) are toxic secondary metabolites naturally occurring in the potato, as well as in certain other Solanaceous plant species, such as tomato, eggplant and pepper. To investi...
Oxpholipin 11D: an anti-inflammatory peptide that binds cholesterol and oxidized phospholipids.PLoS ONE 5 , e10181, (2010)
Many gram-positive bacteria produce pore-forming exotoxins that contain a highly conserved, 12-residue domain (ECTGLAWEWWRT) that binds cholesterol. This domain is usually flanked N-terminally by argi...