Naloxone hydrochloride dihydrate

Names

[ Name ]:
Naloxone hydrochloride dihydrate

[Synonym ]:
(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one,dihydrate,hydrochloride
(5α)-17-Allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one hydrochloride dihydrate
Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)-, (5α)-, hydrochloride, hydrate (1:1:2)
EINECS 206-611-0
MFCD00150901
Naloxone HCl Dihydrate
Naloxone hydrochloride dihydrate

Chemical & Physical Properties

[ Melting Point ]:
182 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₉H₂₆ClNO₆

[ Molecular Weight ]:
399.866

[ Flash Point ]:
288.4ºC

[ Exact Mass ]:
399.144867

[ PSA ]:
88.46000

[ LogP ]:
1.91270

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light.

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25-S26-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Sympathetic activity induced by naloxone-precipitated morphine withdrawal is blocked in genetically engineered mice lacking functional CRF1 receptor.

Toxicol. Appl. Pharmacol. 283(1) , 42-9, (2015)

There is large body evidence indicating that stress can lead to cardiovascular disease. However, the exact brain areas and the mechanisms involved remain to be revealed. Here, we performed a series of...

Relationship between noradrenaline release in the locus coeruleus and antiallodynic efficacy of analgesics in rats with painful diabetic neuropathy.

Life Sci. 92(23) , 1138-44, (2013)

In animal models of neuropathic pain, the noradrenergic descending pain inhibitory pathways from the locus coeruleus (LC) may be suppressed. However, no study has investigated the correlation between ...

Effects of tramadol on substantia gelatinosa neurons in the rat spinal cord: an in vivo patch-clamp analysis.

PLoS ONE 10 , e0125147, (2015)

Tramadol is thought to modulate synaptic transmissions in the spinal dorsal horn mainly by activating µ-opioid receptors and by inhibiting the reuptake of monoamines in the CNS. However, the precise m...