NU-7163

Names

[ Name ]:
NU-7163

[Synonym ]:
2-(2-methylmorpholin-4-yl)-4H-benzo[h]chromen-4-one
4H-Naphtho[1,2-b]pyran-4-one, 2-(2-methyl-4-morpholinyl)-
2-(2-Methyl-4-morpholinyl)-4H-benzo[h]chromen-4-one
2-(2-methylmorpholin-4-yl)benzo(h)chromen-4-one

Biological Activity

[Description]:

A poten and selective, ATP-competitive DNA-PK inhibitor with IC50 of 0.19 uM, Ki of 24 nM; exhibits selectivity for DNA-PK versus related enzymes ATM, ATR, mTOR, and p110α; sensitizes the HeLa cells to the cytotoxic effects of ionizing radiation in vitro.

[References]

References 1. Griffin RJ, et al. J Med Chem. 2005 Jan 27;48(2):569-85. View Related Products by Target DNA-PK

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
461.3±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₇NO₃

[ Molecular Weight ]:
295.332

[ Flash Point ]:
232.8±28.7 °C

[ Exact Mass ]:
295.120850

[ LogP ]:
3.78

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.646

Related Compounds

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