Cyclopyrimorate

Names

[ Name ]:
Cyclopyrimorate

[Synonym ]:
H-965
SW-065
6-chloro-3-(2-cyclopropyl-6-methylphenoxy)-4-pyridazinyl 4-morpholinecarboxylate
[6-chloro-3-(2-cyclopropyl-6-methylphenoxy)pyridazin-4-yl] morpholine-4-carboxylate
6-chloro-3-(2-cyclopropyl-6-methylphenoxy)pyridazin-4-yl morpholine-4-carboxylate
Cyclopyrimorate

Biological Activity

[Description]:

Cyclopyrimorate, a highly effective bleaching herbicide for weed control in rice fields, targets homogentisate solanesyltransferase (HST). HST is a downstream enzyme of 4-hydroxyphenylpyruvate dioxygenase in the plastoquinone (PQ) biosynthesis pathway[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[In Vitro]

Cyclopyrimorate-dependent bleaching effect on Arabidopsis thaliana is reversed by decyl PQ, suggesting that this symptom is attributable to the inhibition of PQ biosynthesis[1].

[References]

[1]. Shino M, et al. In vivo and in vitro evidence for the inhibition of homogentisate solanesyltransferase by cyclopyrimorate. Pest Manag Sci. 2019 Nov 27.

[2]. Shino M, et al. Action mechanism of bleaching herbicide cyclopyrimorate, a novel homogentisate solanesyltransferase inhibitor. J Pestic Sci. 2018 Nov 20;43(4):233-239.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₀ClN₃O₄

[ Molecular Weight ]:
389.83300

[ Exact Mass ]:
389.11400

[ PSA ]:
73.78000

[ LogP ]:
3.87700