RP106

Names

[ Name ]:
RP106

[Synonym ]:
7-butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine
7-n-Butyl-6-(4-hydroxyphenyl)[5H]-pyrrolo[2,3-b]pyrazine

Biological Activity

[Description]:

Aloisine RP106 (compound 38) is a potent inhibitor of Cdk1/cyclin B, Cdk5/p25, and GSK3 with IC50s of 0.70µM, 1.5µM, 0.92 µM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

Research Areas >> Neurological Disease

Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[Target]

Cdk1/cyclin B:0.7 μM (IC50)

Cdk5/p25:1.5 μM (IC50)

GSK-3:0.92 μM (IC50)

[References]

[1]. Yvette Mettey, et al. Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36.

Chemical & Physical Properties

[ Density]:
1.155g/cm3

[ Melting Point ]:
182-184ºC

[ Molecular Formula ]:
C₁₆H₁₇N₃O

[ Molecular Weight ]:
267.32600

[ Exact Mass ]:
267.13700

[ PSA ]:
61.80000

[ LogP ]:
3.67310

[ Index of Refraction ]:
1.613

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335-H413

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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