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Vinburnine

Names

[ CAS No. ]:
4880-88-0

[ Name ]:
Vinburnine

[Synonym ]:
Eburnamenin-14-one, 14,15-dihydro-, (3α,16α)-
(13aS,13bS)-13a-éthyl-2,3,6,13,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij]-1,5-naphtyridin-12(5H)-one
(3α,16α)-14,15-Dihydroeburnamenin-14-one
3a,16a-Eburnamonine
vinburnine
(-)-EBURNAMONINE
(3a,16a)-Eburnamenin-14(15H)-one
(13aS,13bS)-13a-Ethyl-2,3,6,13,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-12(5H)-one
Eburnamenin-14(15H)-one, (3α,16α)-
Vincamone
MFCD00064309
16-Oxoeburnane
(3a,16a)-Eburnamin-14(15H)-one
EINECS 225-490-5
(13aS,13bS)-13a-Ethyl-2,3,6,13,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij]-1,5-naphthyridin-12(5H)-on
cis-Vincamone

Biological Activity

[Description]:

Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Cardiovascular Disease

[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
441.9±33.0 °C at 760 mmHg

[ Melting Point ]:
174-177 °C(lit.)

[ Molecular Formula ]:
C19H22N2O

[ Molecular Weight ]:
294.391

[ Flash Point ]:
221.0±25.4 °C

[ Exact Mass ]:
294.173218

[ PSA ]:
25.24000

[ LogP ]:
3.79

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.719

[ Storage condition ]:
-20℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YY8575570
CHEMICAL NAME :
Vincamone
CAS REGISTRY NUMBER :
4880-88-0
LAST UPDATED :
199703
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C19-H22-N2-O
MOLECULAR WEIGHT :
294.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3852453
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
265 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 14,160,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
28 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 14,160,1978

Safety Information

[ Safety Phrases ]:
S22-S24/25

[ WGK Germany ]:
2

[ RTECS ]:
YY8575570

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%