scyllo-Inositol

Names

[ CAS No. ]:
488-59-5

[ Name ]:
scyllo-Inositol

[Synonym ]:
ELND 005
MFCD00065455
Cocositol
AZD 103
1,3,5 2,4,6-Hexahydroxycyclohexane
SCYLLITO
scyllo-Cyclohexanehexol
(1a,2b,3a,4b,5a,6b)-Cyclohexanehexol
cyclohexane-1r,2t,3c,4t,5c,6t-hexaol
1,3,5 2,4,6-Hexahydroxycyclohexane DTLET
1,2,3,4,5,6-Cyclohexanehexol, (1α,2β,3α,4β,5α,6β)-
Scyllitol
Inositol,scyllo
1,3,5/2,4,6-HEXAHYDROXYCYCLOHEXANE
Quercinitol
(1r,2r,3r,4r,5r,6r)-1,2,3,4,5,6-Cyclohexanehexol
(1r,2r,3r,4r,5r,6r)-Cyclohexane-1,2,3,4,5,6-hexol
1,3,5/2,4,6-Inositol
scyllo-Inositol
scyllo-inosotol

Biological Activity

[Description]:

Scyllo-Inositol, an amyloid inhibitor, potentialy inhibits α-synuclein aggregation. Scyllo-Inositol stabilizes a non-fibrillar non-toxic form of amyloid-β peptide (Aβ42) in vitro, reverses cognitive deficits, and reduces synaptic toxicity and loweres amyloid plaques in an Alzheimer's disease mouse model[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Ibrahim T, et al. α-Synuclein aggregation, seeding and inhibition by scyllo-inositol. Biochem Biophys Res Commun. 2016 Jan 15;469(3):529-34.

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
291.3±40.0 °C at 760 mmHg

[ Melting Point ]:
350ºC

[ Molecular Formula ]:
C₆H₁₂O₆

[ Molecular Weight ]:
180.156

[ Flash Point ]:
143.4±21.9 °C

[ Exact Mass ]:
180.063385

[ PSA ]:
121.38000

[ LogP ]:
-2.11

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.784

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2906199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2906199090

[ Summary ]:
2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Verifying the botanical authenticity of commercial tannins through sugars and simple phenols profiles.

Food Chem. 206 , 274-83, (2016)

Commercial tannins from several botanical sources and with different chemical and technological characteristics are used in the food and winemaking industries. Different ways to check their botanical ...

High cerebral scyllo-inositol: a new marker of brain metabolism disturbances induced by chronic alcoholism.

MAGMA 17(1) , 47-61, (2004)

Cerebral metabolic changes that concur to motor and/or cognitive disorders in actively drinking alcoholics are not well established. We tested the hypothesis that chronic alcoholics exhibit profound a...

β-Amyloid peptides and amyloid plaques in Alzheimer's disease.

Neurotherapeutics 12(1) , 3-11, (2015)

Many lines of evidence support that β-amyloid (Aβ) peptides play an important role in Alzheimer's disease (AD), the most common cause of dementia. But despite much effort the molecular mechanisms of h...