Yohimban-16-carboxylicacid, 17-hydroxy-, methyl ester, (16b,17a)-

Names

[ CAS No. ]:
483-10-3

[ Name ]:
Yohimban-16-carboxylicacid, 17-hydroxy-, methyl ester, (16b,17a)-

[Synonym ]:
RAUHIMBINE
Rauhimbin
Corynanthin
corynanthine free base
corynantine
rauwolscine
Coynanthine
CORYNANTHINE DIHYDRATE

Biological Activity

[Description]:

Corynanthine is a selective α1-adrenergic receptor antagonist. Corynanthine can significantly lower intraocular pressure in rabbits[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Neurological Disease

[References]

[1]. Serle JB, et, al. Corynanthine and aqueous humor dynamics in rabbits and monkeys. Arch Ophthalmol. 1984 Sep;102(9):1385-8.

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Boiling Point ]:
543ºC at 760mmHg

[ Melting Point ]:
225-230ºC

[ Molecular Formula ]:
C₂₁H₂₆N₂O₃

[ Molecular Weight ]:
354.44

[ Exact Mass ]:
354.19400

[ PSA ]:
65.56000

[ LogP ]:
2.58500

[ Vapour Pressure ]:
1.27E-12mmHg at 25°C

[ Index of Refraction ]:
1.66

MSDS

Click to get detail MSDS

Safety Information

[ Risk Phrases ]:
25

[ Safety Phrases ]:
1-20-45

[ RIDADR ]:
UN 1544

[ WGK Germany ]:
3

Precursor & DownStream

Precursor

DownStream

Related Compounds

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