Morin

Names

[ CAS No. ]:
480-16-0

[ Name ]:
Morin

[Synonym ]:
Aluminum Ionophore I
Aurantica
Morin
Morin hydrate
EINECS 207-542-9
MFCD00006826
2',3,4',5,7-Pentahydroxyflavone
2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one
Bois d'Arc
4H-1-Benzopyran-4-one, 2- (2,4-dihydroxyphenyl)-3,5,7-trihydroxy-
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-
Calico Yellow
Al-Morin
Osage Orange

Biological Activity

[Description]:

Morin, a plant-derived flavonoid, possesses low antioxidant activity. Morin is a fluorescing chelating agent used in aluminum speciation[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Duthie G, et al. Antioxidant capacity of flavonoids in hepatic microsomes is not reflected by antioxidant effects in vivo. Oxid Med Cell Longev. 2012;2012:165127.

[2]. Lian HZ, et al. Morin applied in speciation of aluminium in natural waters and biological samples by reversed-phase high-performance liquid chromatography with fluorescence detection. Anal Bioanal Chem. 2003 Jun;376(4):542-8. Epub 2003 May 9.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
645.5±55.0 °C at 760 mmHg

[ Melting Point ]:
299-300 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₅H₁₀O₇

[ Molecular Weight ]:
302.236

[ Flash Point ]:
249.3±25.0 °C

[ Exact Mass ]:
302.042664

[ PSA ]:
131.36000

[ LogP ]:
1.61

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.823

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
methanol: 50 mg/mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK8749000

CHEMICAL NAME :: Flavone, 2',3,4',5,7-pentahydroxy-

CAS REGISTRY NUMBER :: 480-16-0

BEILSTEIN REFERENCE NO. :: 0327474

LAST UPDATED :: 199801

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H10-O7

MOLECULAR WEIGHT :: 302.25

WISWESSER LINE NOTATION :: T66 BO EVJ CR BQ DQ& DQ GQ IQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 555 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 10 umol/L

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 35,443,1997

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ WGK Germany ]:
3

[ RTECS ]:
LK8749000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

The toxicity of NaF on BmN cells and a comparative proteomics approach to identify protein expression changes in cells under NaF-stress: impact of NaF on BmN cells.

J. Hazard. Mater. 286 , 624-31, (2015)

Fluorides negatively affect the development of organisms and are a threat to human health and environmental safety. In this study, Bombyx mori N cell line (BmN) were used to explore effects of NaF on ...

In vitro effects of myricetin, morin, apigenin, (+)-taxifolin, (+)-catechin, (-)-epicatechin, naringenin and naringin on cytochrome b5 reduction by purified NADH-cytochrome b5 reductase.

Toxicology 308 , 34-40, (2013)

The microsomal NADH-dependent electron transport system consisting of cytochrome b5 reductase and cytochrome b5 participates in a number of physiologically important processes including lipid metaboli...

Enhanced oral bioavailability of morin administered in mixed micelle formulation with PluronicF127 and Tween80 in rats.

Biol. Pharm. Bull. 38(2) , 208-17, (2015)

To overcome the low oral bioavailability of morin, a mixed micelle formulation with pharmaceutical excipients that facilitate solubilization and modulate P-glycoprotein (P-gp) was developed and evalua...