Hippeastrine

Names

[ CAS No. ]:
477-17-8

[ Name ]:
Hippeastrine

[Synonym ]:
Hippeastrine

Biological Activity

[Description]:

Hippeastrine, an active alkaloid, exhibits a good dose-dependent inhibitory effect against topoisomerase I (Top I) with an IC50 at 7.25 μg/mL. Antiproliferative and anticancer activities[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[In Vitro]

Hippeastrine strongly inhibits the proliferation of HT-29 and Hep G2 cells in an intuitive dose-dependent manner with the IC50s at 3.98 μg/mL and 11.85 μg/mL, respectively, and also induces significant cellular morphological changes, which further validate our screening method and the potent antineoplastic effects[1].

[References]

[1]. Chen GL, et al. Antiproliferative activities of Amaryllidaceae alkaloids from Lycoris radiata targeting DNA topoisomerase I. Sci Rep. 2016;6:38284. Published 2016 Dec 6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₇NO₅

[ Molecular Weight ]:
315.32100

[ Exact Mass ]:
315.11100

[ PSA ]:
68.23000

[ LogP ]:
0.98080

Related Compounds

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