Antitubercular agent-33

Names

[ Name ]:
Antitubercular agent-33

[Synonym ]:
2-Nitro-N-[4-(2-pyridinyl)-1,3-thiazol-2-yl]benzamide
Benzamide, 2-nitro-N-[4-(2-pyridinyl)-2-thiazolyl]-

Biological Activity

[Description]:

Antitubercular agent-33 is a 2-aminothiazole derivative, shows potent antintubercular activity against Mycobacterium tuberculosis (Mtb)[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Antitubercular agent-33 (compound 49) exerts antitubercular effects with MIC values of 1.6-3.1 μM (in 7H9-glucose media) and 0.78 μM (in GAST media), respectively[1].

[References]

[1]. Meissner A, et al. Structure-activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis. Bioorg Med Chem. 2013 Nov 1;21(21):6385-97.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₁₅H₁₀N₄O₃S

[ Molecular Weight ]:
326.330

[ Exact Mass ]:
326.047363

[ LogP ]:
2.47

[ Index of Refraction ]:
1.710

Related Compounds

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