Trihexosylceramide (d18:1/12:0)

Names

[ Name ]:
Trihexosylceramide (d18:1/12:0)

[Synonym ]:
D-lactosyl-ß-1,1' N-lauroyl-D-erythro-sphingosine

Biological Activity

[Description]:

Trihexosylceramide (d18:1/12:0) is a type of Trihexosylceramide. In the renal tissue of heterozygous Fabry's disease, the cytoplasm of glomerular epithelial cells appears foamy. Trihexosylceramide accumulated in glomerular epithelial cells as identified by immunostaining[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Wang JR, et al. Improved sphingolipidomic approach based on ultra-high performance liquid chromatography and multiple mass spectrometries with application to cellular neurotoxicity. Anal Chem. 2014 Jun 17;86(12):5688-96.

[2]. Fukushima M, et al. A female heterozygous patient with Fabry's disease with renal accumulation of trihexosylceramide detected with a monoclonal antibody. Am J Kidney Dis. 1995 Dec;26(6):952-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₂H₇₉NO₁₃

[ Molecular Weight ]:
806.08

[ Exact Mass ]:
805.55500

[ PSA ]:
231.35000

[ LogP ]:
4.49130

[ Storage condition ]:
-20°C

Related Compounds

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