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DSPE-PEG(2000)-Amine

Names

[ CAS No. ]:
474922-26-4

[ Name ]:
DSPE-PEG(2000)-Amine

[Synonym ]:
Octadecanoic acid, 1-[[[[2-[[[2-(2-aminoethoxy)ethoxy]carbonyl]amino]ethoxy]hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester, ammonium salt
35-Amino-24-hydroxy-24-oxido-18,29-dioxo-19,23,25,30,33-pentaoxa-28-aza-24λ5-phosphapentatriacontan-21-yl octadecanoate ammoniate (1:1)

Biological Activity

[Description]:

DSPE-PEG(2000)-Amine is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents[1][2][3].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

DSPE-PEG(2000)-Amine is coated on the surface of the fluorescein diacetate (FDA) nanocrystals to provide a interface for the antibody coupling. The FDA[DSPE-PEG(2000)Amine]-modified biolabels have a highly stable colloidal suspension with minimized nonspecific interactions. The adsorbed DSPE-PEG(2000)Amine layer causes the FDA nanocrystals to disperse in water and prevents their aggregation, hence conferring colloidal stability[3].

[References]

[1]. Feilong Sun, et al. A Mixed Micelle Formulation for Oral Delivery of Vitamin K. Pharm Res. 2016 Sep;33(9):2168-79.

[2]. Brian R Sloat, et al. In Vitro and in Vivo Anti-Tumor Activities of a Gemcitabine Derivative Carried by Nanoparticles. Int J Pharm. 2011 May 16;409(1-2):278-88.

[3]. Cangel Pui-yee Chan, et al. Nanocrystal Biolabels With Releasable Fluorophores for Immunoassays. Anal Chem. 2004 Jul 1;76(13):3638-45.

Chemical & Physical Properties

[ Molecular Formula ]:
(C2H4O)nC44H87N2O10P.NH3

[ Molecular Weight ]:
896.226

[ Exact Mass ]:
895.662598

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Class ]:
6.1

Related Compounds