(3β,5α,6β)-Androstane-3,5,6-triol

Names

[ Name ]:
(3β,5α,6β)-Androstane-3,5,6-triol

[Synonym ]:
androstane-3β,5α,6β-triol
Androstane-3,5,6-triol, (3β,5α,6β)-
Androstan-3β,5α,6β-triol
5α-androstane-3β,5,6β-triol
(3β,5α,6β)-Androstane-3,5,6-triol

Biological Activity

[Description]:

5α-Androstane-3β,5,6β-triol is a neuroprotectant. 5α-Androstane-3β,5,6β-triol can remarkably reverse intracellular acidification and alleviate neuronal injury through the inhibition of AMPK signaling. 5α-Androstane-3β,5,6β-triol remarkably reduced the infarct volume and attenuated neurologic impairment in acute ischemic stroke models of middle cerebral artery occlusion in vivo[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> AMPK

Signaling Pathways >> PI3K/Akt/mTOR >> AMPK

Research Areas >> Neurological Disease

[Target]

AMPK[1]

[References]

[1]. Xue D, et al. TRIOL Inhibits Rapid Intracellular Acidification and Cerebral Ischemic Injury: The Role of Glutamate in Neuronal Metabolic Reprogramming. ACS Chem Neurosci. 2022 Jun 30.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
430.1±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₃₂O₃

[ Molecular Weight ]:
308.456

[ Flash Point ]:
193.1±20.5 °C

[ Exact Mass ]:
308.235138

[ PSA ]:
60.69000

[ LogP ]:
3.88

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.580

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.