7-Ketolithocholic acid

Names

[ Name ]:
7-Ketolithocholic acid

[Synonym ]:
3-Hydroxy-7-oxocholan-24-oic acid
3α-Hydroxy-7-keto-5β-cholanic Acid
EINECS 225-083-2
3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID
4-(3-Hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
3α-Hydroxy-7-oxo-5β-cholanic Acid
Cholan-24-oic acid, 3-hydroxy-7-oxo-
3a-Hydroxy-7-oxo-5b-cholanic acid

Biological Activity

[Description]:

7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid), a bile acid, can be absorbed and suppresses endogenous bile acid production and biliary cholesterol secretion[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite

[In Vitro]

Bile acids are main components of mammalian bile. They are steroid carboxylic acids that synthesized from cholesterol in liver tissue[1].

[References]

[1]. Choucair I, et al. Quantification of bile acids: a mass spectrometry platform for studying gut microbe connectionto metabolic diseases. J Lipid Res. 2020 Feb;61(2):159-177.

[2]. Salen G, et al. Effect of 7-ketolithocholic acid on bile acid metabolism in humans. Gastroenterology. 1982 Aug;83(2):341-7.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
545.9±25.0 °C at 760 mmHg

[ Melting Point ]:
205ºC

[ Molecular Formula ]:
C₂₄H₃₈O₄

[ Molecular Weight ]:
390.556

[ Flash Point ]:
298.0±19.7 °C

[ Exact Mass ]:
390.277008

[ PSA ]:
74.60000

[ LogP ]:
4.25

[ Vapour Pressure ]:
0.0±3.3 mmHg at 25°C

[ Index of Refraction ]:
1.535

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
22-24/25

[ HS Code ]:
2918990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

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