Larixyl acetate

Names

[ Name ]:
Larixyl acetate

[Synonym ]:
Larixylacetat
Larixol-monoacetat
6-Acetyllarixol

Biological Activity

[Description]:

Larixyl acetate is a potent and selective TRPC6 inhibitor with IC50 values of 0.58 μM and 6.83 μM against hTRPC6-YFP and hTRPC3-YFP, respectively. Larixyl acetate prevents HPV and is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Infection

Research Areas >> Neurological Disease

[Target]

hTRPC6:0.58 μM (IC50)

hTRPC3:6.83 μM (IC50)

[References]

[1]. Urban N, et al. Identification and Validation of Larixyl Acetate as a Potent TRPC6 Inhibitor. Mol Pharmacol. 2016 Jan;89(1):197-213.

[2]. Chen X, et al. The TRPC6 inhibitor, larixyl acetate, is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction. J Neuroinflammation. 2019 Jan 31;16(1):21.

Chemical & Physical Properties

[ Density]:
1.00±0.1 g/cm3 (20ºC 760 Torr)

[ Boiling Point ]:
419.3±28.0 °C

[ Melting Point ]:
82ºC

[ Molecular Formula ]:
C₂₂H₃₆O₃

[ Molecular Weight ]:
348.51900

[ Exact Mass ]:
348.26600

[ PSA ]:
46.53000

[ LogP ]:
5.04400

[ Index of Refraction ]:
1.4826 (589.3 nm, 20℃)

[ Storage condition ]:
?20°C

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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