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PA 452

Names

[ CAS No. ]:
457657-34-0

[ Name ]:
PA 452

Biological Activity

[Description]:

PA452, retinoic X receptor (RXR) specific antagonist, inhibits the effect of Retinoic acid (RA) on Th1/Th2 development[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR

[Target]

RXR


[In Vitro]

PA452 inhibits the Troglitazone (TZ)-induced CK13 expression[2]. PA452 (0.01, 0.1, and 1 μM) inhibits RXR in normal human urothelial (NHU) cells[2].

[References]

[1]. Iwata M, et al. Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors. Int Immunol. 2003 Aug;15(8):1017-25.

[2]. Varley CL, et al. Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells. Am J Pathol. 2004 May;164(5):1789-98.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H37N3O3

[ Molecular Weight ]:
439.59

Related Compounds