3-Fluoro-DL-phenylalanine

Names

[ CAS No. ]:
456-88-2

[ Name ]:
3-Fluoro-DL-phenylalanine

[Synonym ]:
3-FLUORO-DL-PHENYLALANINE
EINECS 207-272-1
DL-2-Amino-3-(3-fluorophenyl)propionic acid
2-Amino-3-(3-fluorophenyl)propionic Acid
2-Amino-3-(3-fluorophenyl)propanoic acid
QVYZ1R CF &&DL Form
DL-(3-Fluorophenyl)alanine
m-Fluoro-DL-phenylalanine
m-Fluorophenylalanine
MFCD00004273
Phenylalanine, 3-fluoro-
3-Fluorophenylalanine
H-DL-Phe(3-F)-OH

Biological Activity

[Description]:

H-DL-Phe(3-F)-OH is a phenylalanine derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-819.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
305.0±32.0 °C at 760 mmHg

[ Melting Point ]:
-240ºC(dec.)

[ Molecular Formula ]:
C₉H₁₀FNO₂

[ Molecular Weight ]:
183.180

[ Flash Point ]:
138.3±25.1 °C

[ Exact Mass ]:
183.069550

[ PSA ]:
63.32000

[ LogP ]:
1.16

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.555

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY6300000

CHEMICAL NAME :: Alanine, 3-(m-fluorophenyl)-

CAS REGISTRY NUMBER :: 456-88-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H10-F-N-O2

MOLECULAR WEIGHT :: 183.20

WISWESSER LINE NOTATION :: QVYZ1R CF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 73,176,1941

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R37

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922499990

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Hidden overflow pathway to L-phenylalanine in Pseudomonas aeruginosa.

J. Bacteriol. 154(2) , 623-31, (1983)

Pseudomonas aeruginosa is representative of a large group of pseudomonad bacteria that possess coexisting alternative pathways to L-phenylalanine (as well as to L-tyrosine). These multiple flow routes...

19F n.m.r. studies of conformational changes accompanying cyclic AMP binding to 3-fluorophenylalanine-containing cyclic AMP receptor protein from Escherichia coli.

Biochem. J. 287 ( Pt 2) , 627-32, (1992)

A fluorine-containing analogue of the cyclic AMP (cAMP) receptor protein (CRP) from Escherichia coli was prepared by biosynthetic incorporation of 3-fluorophenylalanine (3-F-Phe). 19F n.m.r. studies o...

Fluorine-19 nuclear magnetic resonance spectroscopic study of fluorophenylalanine- and fluorotryptophan-labeled avian egg white lysozymes.

Biochemistry 33(17) , 5238-45, (1994)

We report the 470-MHz (11.7 T) 19F solution nuclear magnetic resonance (NMR) spectra of 2-, 3-, and 4-fluorophenylalanine incorporated into the egg white lysozymes (EC 3.2.1.17) of chicken, pheasant, ...