Estrone sulfate sodium
Names
[ CAS No. ]:
438-67-5
[ Name ]:
Estrone sulfate sodium
[Synonym ]:
Estra-1(10),2,4-trien-17-one, 3-(sulfooxy)-, sodium salt (1:1)
Sodium 17-oxoestra-1(10),2,4-trien-3-yl sulfate
Estrone 3-sulfate sodium salt
Estrone sodium sulfate
Estrone sulfate sodium
Estrone-3-sulfate sodium salt
estrone sodium sulphate
Sodium estrone 3-sulfate
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Human Endogenous Metabolite
[In Vitro]
[References]
Chemical & Physical Properties
[ Density]:
1.349 g/cm3
[ Melting Point ]:
258-260°C
[ Molecular Formula ]:
C18H21NaO5S
[ Molecular Weight ]:
372.41
[ Exact Mass ]:
372.100739
[ PSA ]:
91.88000
[ LogP ]:
4.03160
[ Storage condition ]:
-20°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KG8775000
- CHEMICAL NAME :
- Estrone, hydrogen sulfate, sodium salt
- CAS REGISTRY NUMBER :
- 438-67-5
- LAST UPDATED :
- 199509
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C18-H22-O5-S.Na
- MOLECULAR WEIGHT :
- 373.45
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 504 ug/kg
- SEX/DURATION :
- female 9 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - menstrual cycle changes or disorders
- REFERENCE :
- JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 55,191,1979
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H315-H319-H335-H350
[ Precautionary Statements ]:
P201-P261-P305 + P351 + P338-P308 + P313
[ Hazard Codes ]:
T: Toxic;
[ Risk Phrases ]:
R45-36/37/38
[ Safety Phrases ]:
S53-45-26
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
KG8775000
Precursor & DownStream
Precursor
DownStream
Articles
J. Pharm. Sci. 102(1) , 280-8, (2013)
We aimed to explore the major active components in grapefruit juice (GFJ), orange juice (OJ), and apple juice (AJ) that are responsible for OATP2B1-mediated drug interactions, by means of in vitro stu...
Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: addressing methodologic issues of plasma membrane isolation and expression-activity relationship.Drug Metab. Dispos. 43(2) , 284-8, (2015)
To predict transporter-mediated drug disposition using physiologically based pharmacokinetic models, one approach is to measure transport activity and relate it to protein expression levels in cell li...
Inclusion of endogenous hormone levels in risk prediction models of postmenopausal breast cancer.J. Clin. Oncol. 32(28) , 3111-7, (2014)
Endogenous hormones are risk factors for postmenopausal breast cancer, and their measurement may improve our ability to identify high-risk women. Therefore, we evaluated whether inclusion of plasma es...