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(S)-Butaprost free acid

Names

[ CAS No. ]:
433219-55-7

[ Name ]:
(S)-Butaprost free acid

[Synonym ]:
17,20-Cycloprost-13-en-1-oic acid, 11,16-dihydroxy-9-oxo-17-propyl-, (11α,13E,16S)-
17,20-Cycloprost-13-en-1-oic acid, 11,16-dihydroxy-9-oxo-17-propyl-, (11α,13E,16R)-
9-oxo-11alpha,16s-dihydroxy-17-cyclobutyl-prost-13e-en-1-oic acid
Cyclopentaneheptanoic acid, 3-hydroxy-2-[(1E,4R)-4-hydroxy-4-(1-propylcyclobutyl)-1-buten-1-yl]-5-oxo-, (1R,2R,3R)-
9-oxo-11alpha,16r-dihydroxy-17-cyclobutyl-prost-13e-en-1-oic acid
7-{(1R,2R,3R)-3-Hydroxy-2-[(1E,4R)-4-hydroxy-4-(1-propylcyclobutyl)-1-buten-1-yl]-5-oxocyclopentyl}heptanoic acid
(11α,13E,16S)-11,16-Dihydroxy-9-oxo-17-propyl-17,20-cycloprost-13-en-1-oic acid
(11α,13E,16R)-11,16-Dihydroxy-9-oxo-17-propyl-17,20-cycloprost-13-en-1-oic acid

Biological Activity

[Description]:

(S)-Butaprost (free acid) is a potent and highly selective agonist of EP2 receptor[1].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[Target]

EP2[1]


[References]

[1]. Tani K, et al. Development of a highly selective EP2-receptor agonist. Part 2: identification of 16-hydroxy-17,17-trimethylene 9beta-chloro PGF derivatives. Bioorg Med Chem. 2002;10(4):1107-1114.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
565.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H38O5

[ Molecular Weight ]:
394.545

[ Flash Point ]:
310.0±26.6 °C

[ Exact Mass ]:
394.271912

[ PSA ]:
94.83000

[ LogP ]:
3.04

[ Vapour Pressure ]:
0.0±3.5 mmHg at 25°C

[ Index of Refraction ]:
1.558

Related Compounds