THP-PEG7

Names

[ Name ]:
THP-PEG7

[Synonym ]:
4-methoxy-5,5-dimethyl-5H-oxazol-2-one
4-Methoxy-5,5-dimethyl-5H-oxazol-2-on

Biological Activity

[Description]:

THP-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. THP-PEG6-OH is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Non-cleavable

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

[2]. Masahiro Tomita, et al. Antibody specifically recognizing resin plasticizer compound. WO2005105846A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₃₄O₈

[ Molecular Weight ]:
232.23900

[ Exact Mass ]:
232.09600

[ PSA ]:
69.90000

[ LogP ]:
0.90320

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

Related Compounds

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