Glp-His-Pro-Gly-NH2

Names

[ CAS No. ]:
41880-59-5

[ Name ]:
Glp-His-Pro-Gly-NH2

[Synonym ]:
Glycinamide,5-oxo-L-prolyl-L-histidyl-L-prolyl
pGlu-His-Pro-Gly-NH2

Biological Activity

[Description]:

Glp-His-Pro-Gly-NH2 (pGlu-His-Pro-Gly-NH2) is a peptide containing 4 amino acids. Glp-His-Pro-Gly-NH2 stimulates gonadotrophin, luteinizing hormone (LH) and follicle stimulating hormone (FSH) release[1][2].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> Others >> Others

[In Vitro]

Glp-His-Pro-Gly-NH2 (pGlu-His-Pro-Gly-NH2; 6.6 μg/mL; 人胎儿垂体) 分别诱导黄体生成素 (LH) 和卵泡刺激素 (FSH) 释放 85% 和 96%[2]。

[References]

[1]. Visser TJ, et, al. A new radioimmunoassay of thyrotropin-releasing hormone. FEBS Lett. 1977 Nov 1;83(1):37-40.   

[2]. Groom GV, et, al. Gonadotrophin release from human foetal pituitary cultures induced by fragments of the luteinizing hormone-releasing hormone. FEBS Lett. 1973 Jun 15;33(1):57-60.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H25N7O5

[ Molecular Weight ]:
419.43500

[ Exact Mass ]:
419.19200

[ PSA ]:
190.84000

[ LogP ]:
0.35220

Related Compounds

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