CMPD-1

Names

[ Name ]:
CMPD-1

[Synonym ]:
CMPD1
MK2a Inhibitor
Mitogen-activated protein kinase-activated protein kinase 2a Inhibitor
MAPKAPK2a Inhibitor

Biological Activity

[Description]:

CMPD1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with apparent Ki (Kiapp) of 330 nM[1][2].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> MAPKAPK2 (MK2)

Research Areas >> Cancer

[Target]

Kiapp: 330 nM (MK2 phosphorylation)[2]

[In Vitro]

CMPD1 does not inhibit p38 MAPK-mediated phosphorylation of other two substrates, MBP and ATF2[1].

[References]

[1]. Gurgis F, et al. Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2. Cell Death Discov. 2015 Sep 7;1:15028.

[2]. Davidson W, er al. Discovery and characterization of a substrate selective p38alpha inhibitor. Biochemistry. 2004 Sep 21;43(37):11658-71.

Chemical & Physical Properties

[ Density]:
1.229g/cm3

[ Boiling Point ]:
585ºC at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₀FNO₂

[ Molecular Weight ]:
349.40

[ Flash Point ]:
307.6ºC

[ Exact Mass ]:
349.14800

[ PSA ]:
49.33000

[ LogP ]:
5.23270

[ Index of Refraction ]:
1.627

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds

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