lipiferolide

Names

[ Name ]:
lipiferolide

[Synonym ]:
Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, 7-(acetyloxy)-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylene-, (1aR,4E,7R,7aR,10aS,10bR)-
(1aR,4E,7R,7aR,10aS)-1a,5-Dimethyl-8-methylene-9-oxo-1a,2,3,6,7,7a,8,9,10a,10b-decahydrooxireno[9,10]cyclodeca[1,2-b]furan-7-yl acetate
Lipiferolide
Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, 7-(acetyloxy)-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylene-, (1aR,4E,7R,7aR,10aS)-
8.beta.-Acetoxy-parthenolide
Lipiferolid
(1aR,4E,7R,7aR,10aS,10bR)-1a,5-Dimethyl-8-methylene-9-oxo-1a,2,3,6,7,7a,8,9,10a,10b-decahydrooxireno[9,10]cyclodeca[1,2-b]furan-7-yl acetate

Biological Activity

[Description]:

Lipiferolide is an antiplasmodial agent (IC50: 1.8 μg/mL) that can be isolated from Liriodendron tulipifera. Lipiferolide also inhibits FPTase, and has antitumor activity[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> Farnesyl Transferase

[References]

[1]. Graziose R, et al. Antiplasmodial activity of aporphine alkaloids and sesquiterpene lactones from Liriodendron tulipifera L. J Ethnopharmacol. 2011 Jan 7;133(1):26-30.

[2]. Moon MK, et al. Farnesyl protein transferase and tumor cell growth inhibitory activities of lipiferolide isolated from Liriodendron tulipifera. Arch Pharm Res. 2007 Mar;30(3):299-302.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
444.8±45.0 °C at 760 mmHg

[ Melting Point ]:
118-119 °C

[ Molecular Formula ]:
C₁₇H₂₂O₅

[ Molecular Weight ]:
306.35

[ Flash Point ]:
196.3±28.8 °C

[ Exact Mass ]:
306.146729

[ PSA ]:
65.13000

[ LogP ]:
2.13

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.531

Related Compounds

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