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Amitifadine

Names

[ CAS No. ]:
410074-73-6

[ Name ]:
Amitifadine

[Synonym ]:
EB-1010
(5S)-5-(3,4-dichlorocyclohexa-2,4-dien-1-yl)bicyclo[3.1.0]hexane
(1R,5S)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane
DOV-21,947
GE0J375F8F
Amitifadine
5W2YA6F455
3-Azabicyclo[3.1.0]hexane, 1-(3,4-dichlorophenyl)-, (1R,5S)-
UNII:5W2YA6F455

Biological Activity

[Description]:

A triple monoamine reuptake inhibitor, inhibits the reuptake of 5-HT, norepinephrine and dopamine in HEK 293 cells with IC50 of 12, 23 and 96 nM, respectively; reduces the duration of immobility in the forced swim test in rats with an oral minimum effective dose (MED) of 5 mg/kg. Depression Phase 3 Clinical

[References]

References 1. Skolnick P, et al. Eur J Pharmacol. 2003 Feb 14;461(2-3):99-104. 2. Warnock KT, et al. Pharmacol Biochem Behav. 2012 Nov;103(1):111-8. View Related Products by Target Monoamine Transporter Depression

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
324.4±37.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H11Cl2N

[ Molecular Weight ]:
228.118

[ Flash Point ]:
150.0±26.5 °C

[ Exact Mass ]:
227.026855

[ LogP ]:
2.57

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.622

Related Compounds